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Study to assess whether left atrial appendage ligation during coronary artery bypass grafting changes the incidence of stroke and atrial fibrillation in post operative period when compared to coronary artery bypass grafting without left atrial appendage ligation

A PROSPECTIVE RANDOMIZED COMPARISON OF INCIDENCE OF ATRIAL FIBRILLATION AND STROKE IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING WITH OR WITHOUT LEFT ATRIAL APPENDAGE LIGATION

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/09/015571
Enrollment
200
Registered
2018-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing elective Coronary Artery Bypass Grafting

Interventions

Intervention1: CABG with LAA ligation: Coronary Artery Bypass Grafting with Left Atrial Appendage Ligation Control Intervention1: CABG without LAA ligation: Coronary Artery Bypass Graftin with Left At

Sponsors

CNC AIIMS as a part of CABG package
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the adult patients undergoing on pump CABG at high predicted risk of POAF based on the CHA2DS2-VASC scoring system will be included in the study.

Exclusion criteria

Exclusion criteria: Patients with pacemaker in-situ H/o of Cox maze or radio-frequency ablation of atrial arrhythmia Moderate or severe Mitral Stenosis (MS) or Mitral Regurgitation(MR) H/o of Myocardial Infarction in previous 3 months Incomplete pre-op diastolic function assessment Inability to document complete LAA ligation by intra-op TEE Pre-operative echocardiographic evidence of LAA clot

Design outcomes

Primary

MeasureTime frame
1.CABG with and without LAA ligation will be compared for incidence of clinical stroke. 2. CABG with and without LAA ligation will be compared for incidence of clinically detectable atrial fibrillation, ECG detected atrial fibrillation 3. All of the above comparison will be done at different time points of post-operative follow-up.Timepoint: 1. 1 week post operative 2. 1 month post operative 3. 3 months post operative 4. 6 months post operative 5. 12 months post operative—

Secondary

MeasureTime frame
CABG with and without LAA ligation will be compared for incidence of clinically detectable atrial fibrillation, ECG and Holter detected atrial fibrillation and total time duration of atrial fibrillation on Holter. 2. CABG with and without LAA ligation will also be compared for incidence of stroke. 3. All of the above comparison will be done at different time points of post-operative follow-up.Timepoint: 1 week, 1 month, 3 momths, 6 months, 12 months—

Countries

India

Contacts

Public ContactDrAKBisoi

AIIMS

drakbisoi@gmail.com9818330882

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026