A study to compare the effects of desflurane and isoflurane on brain physiology, blood pressure, heart rate and recovery from anesthesia in brain tumor operation.

The comparative effects of desflurane and isoflurane on intraoperative cerebral hemodynamics, cardiovascular changes and postoperative recovery in patients undergoing craniotomy for supratentorial tumors.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/09/015570

Enrollment

Registered

2018-09-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Supratentorial Brain Tumours

Interventions

Intervention1: Desflurane: Desflurane will be administered and maintained at less than or equal to 1 MAC by inhalational route till skin closure,dose will be subsequently adjusted to maintain mean art

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients belonging to either sex between 20 to 60 years of age. 2.Patients with ASA physical status 1 & 2. 3.Patients with Glasgow coma scale 15. 4.Patients undergoing elective craniotomy under general anaesthesia for supratentorial tumours.

Exclusion criteria

Exclusion criteria: 1.Patients refusal to give consent. 2.Patients with significant cardiovascular,pulmonary,renal,hepatic,endocrine or muscular disorders. 3.Patients having tumours with midline shift. 4.Patients allergic to any anaesthetic drug. 5.Patients having surgery related complications like vascular injury,massive intraoperative bleeding or injury to vital structures necessitating elective post operative mechanical ventilation. 6.Patients exposed to general anaesthesia in preceeding 7 days before the study.

Design outcomes

Primary

Measure	Time frame
1.To compare the changes in lumbar cerebrospinal fluid pressure and cerebral perfusion pressure from baseline. 2.To compare the effects of desflurane and isoflurane on intraoperative degree of dural tension and brain swelling.Timepoint: 1.Recorded every 5 minutes until the dura is opened. 2.Assessed at the time of dural opening.	—

Secondary

Measure	Time frame
To compare intraoperative and postoperative haemodynamics.Timepoint: Recorded every 5 minutes until the dura is opened and thereafter every 15 minutes uptil 1 hour postoperatively.;To compare postoperative recovery including emergence and extubation time.Timepoint: At the end of the operation.;To compare time taken to reach an Aldrete Score more than or equal to 9.Timepoint: After the patient is extubated and shifted to the Post Anaesthesia Care Unit.	—

Measure

Time frame

To compare intraoperative and postoperative haemodynamics.Timepoint: Recorded every 5 minutes until the dura is opened and thereafter every 15 minutes uptil 1 hour postoperatively.;To compare postoperative recovery including emergence and extubation time.Timepoint: At the end of the operation.;To compare time taken to reach an Aldrete Score more than or equal to 9.Timepoint: After the patient is extubated and shifted to the Post Anaesthesia Care Unit.

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Countries

India

Contacts

Public ContactDr Amita Acharjee

Institute Of Post Graduate Medical Education and Research

dr.amitaacharya@yahoo.com9831650768

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026