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Effect of melatonin premedication on propofol consumption in GA

To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- a randomised double blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/08/015537
Enrollment
70
Registered
2018-08-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K928- Other specified diseases of the digestive system

Interventions

Intervention1: Melatonin tablet for intervention: Melatonin 3 mg given as premedication Control Intervention1: Placebo: Sugar pellet

Sponsors

Bangalore medical college and research institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient who gives written informed c9nsent, with BMI 18-26kg/m2, scheduled for surgery under General anaesthesia of ASA 1& 2 status.

Exclusion criteria

Exclusion criteria: Pregnant women, patients on benzodiazepines, opioid or sedative drugs, patients with psychiatric illness, IHD, HYPERTENSION.

Design outcomes

Secondary

MeasureTime frame
Pre operative anxiety using hamilton anxiety rating scale. Preoperative sedation using Ramsay sedation scaleTimepoint: 60 min after melatonin consumption preoperatively—

Primary

MeasureTime frame
To assess the effect of oral melatonin as premedication on propofol requirement for induction using entropyTimepoint: During induction.—

Countries

India

Contacts

Public ContactDr Nethra S S

Bangalore medical college and research institute

nethra.surhonne@gmail.com9448171403

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026