A study To evaluate whether tablet Tizanidine(sedative) taken by mouth just before surgery decreases anaesthetic agent consumption in patients undergoing abdomen surgeries

A Randomised Controlled Double Blind Study to Assess the Effect of Oral Tizanidine Premedication on Intraoperative Isoflurane Consumption in Patients Undergoing Laparoscopic Surgeries Under General Anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/08/015527

Enrollment

Registered

2018-08-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Tab Tizanidine 2mg: Patient is administered tab Tizanidine 2mg 70 minutes prior to sugery Intervention2: Tab Tizanidine 4mg: Patient is administered Tab Tizanidine 4mg 70 minutes prior

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA I and II Patients willing to give informed consent

Exclusion criteria

Exclusion criteria: Patient not willing to give informed consent Patients with uncontrolled diabetes, hypertension, cardiovascular, respiratory, renal, hepatic , endocrine disorders Patients with neurological and psychiatric disturbances Patients with history of drug allergies

Design outcomes

Primary

Measure	Time frame
Volume (ml) of isoflurane consumptionTimepoint: Volume (ml) of isoflurane consumption will be noted intraoperatively every half hour till the end of surgery and total consumption at the end of surgery	—

Secondary

Measure	Time frame
1)Effect of oral tizanidine on preoperative and early post operative sedation 2)Safety profile of oral tizanidineTimepoint: 1)sedation using Ramsay sedation scale is recorded every 15 minutes after drug is administered till the patient is taken up for surgery. also post operatively every 15 minutes for first half hour, then every 30 minutes for 2 hours and then every hour for 6 hours 2)side effects will be assessed preoperatively from when drug is administered, intraoperatively and post operatively for 6 hours	—

Measure

Time frame

1)Effect of oral tizanidine on preoperative and early post operative sedation 2)Safety profile of oral tizanidineTimepoint: 1)sedation using Ramsay sedation scale is recorded every 15 minutes after drug is administered till the patient is taken up for surgery. also post operatively every 15 minutes for first half hour, then every 30 minutes for 2 hours and then every hour for 6 hours 2)side effects will be assessed preoperatively from when drug is administered, intraoperatively and post operatively for 6 hours

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Countries

India

Contacts

Public ContactDr Bhargavi Sanket

Bangalore Medical College and Research Institute

bhargavi_doc@yahoo.com9886843423

Outcome results