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Levels of metallothionein in serum, saliva, gingival crevicular fluid and expression in gingival tissues before and after nonsurgical treatment of pyorrhoea in smokers and nonsmokers

Effect of Nonsurgical Periodontal Therapy On Metallothioneins expression and Levels in Serum, Saliva and Gingival Crevicular Fluid: An Interventional Study - NSPT in MT levels

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/08/015427
Enrollment
80
Registered
2018-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B998- Other infectious disease

Interventions

Intervention1: Smokers with chronic periodontitis: Non-surgical periodontal therapy Intervention2: Nonsmokers with chronic periodontitis: Nonsurgical periodontal therapy Control Intervention1: Periodo

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a)Patients in the age group of 20-70 years b)Patients having no evidence of interproximal attach¬ment loss, probing pocket depth (PPD) of =3 mm at any sites on any teeth, and whole-mouth bleeding scores of =10% will serve as controls. c)Patients with chronic generalized periodontitis having at least two or more inter¬proximal sites with an attachment loss of =4 mm, or two or more interproximal sites with PPDs of =5 mm, not on the same tooth. It will be ensured that the total number of teeth in the mouth will be =20.

Exclusion criteria

Exclusion criteria: a)A course of nonsteroidal anti-inflammatory drugs or antimicrobial drugs within a 3-month period before the commencement of study b)Pregnancy or lactating mothers c)Use of mouthwashes or vitamin supplements within the previous 3 months d)Patients with other systemic conditions that could affect the results like diabetes mellitus, hypertension, rheumatoid arthritis, and chronic lung diseases etc.

Design outcomes

Primary

MeasureTime frame
1. Metallothionein(MT) levels in serum, saliva and gingival crevicular fluid 2. MT-mRNA expression in gingival tissuesTimepoint: At baseline only in periodontally healthy individuals and at baseline and after 3 months of nonsurgical periodontal therapy in chronic periodontitis patients—

Secondary

MeasureTime frame
Probing depth (PD), Clinical attachment level (CAL), Gingival Index (Löe and Sillness), Sulcular bleeding index (Muhlemann and Son), Plaque index (Silness and Löe)Timepoint: At baseline only in periodontally healthy individuals and at baseline and after 3 months of nonsurgical periodontal therapy in chronic periodontitis patients—

Countries

India

Contacts

Public ContactVikender Singh

All India Institute of Medical Sciences

vikenderyadav@gmail.com8750860191

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 8, 2026