Health Condition 1: M249- Joint derangement, unspecified
Conditions
Interventions
Intervention1: Tranexamic Acid versus Placebo group: Group 1: 15 mg/kg of TXA in 100 ml of NS administered over a period of 10 minutes before skin incision
Group 2: 15 mg/kg of TXA in 100 ml of NS ad
Sponsors
AIIMS Raipur
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients, 18 â?? 65 years of either sex with ASA grade I and II undergoing primary elective unilateral hip joint arthroplasty by same surgeon.
Exclusion criteria
Exclusion criteria: Patients with a) The absence of written informed consent b) Bilateral arthroplasties c) Complicated primary total hip arthroplasty with previous osteotomy, simultaneous fracture fixation, implant removal or bone grafting, History of thromboembolic diseases, d) The presence of clotting disorder or current treatment with an antiplatelet agent, anticoagulant or deep vein thrombosis (DVT) prophylaxis in the perioperative period, e) Renal disease f) History of the previous allergy to TXA. g) History of labile or uncontrolled hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a. Drop in Hct after 24 hours b. Blood transfusion requirement in the first 24 hoursTimepoint: Pre-op Hb/Hct: Post-op Hb/Hct: Immediately after surgery: 24 hours after surgery: 48 hours after surgery: Drain output: 3 hours after surgery: 6 hours after surgery: 12 hours after surgery: 24 hours after surgery: | — |
Secondary
| Measure | Time frame |
|---|---|
| c. Decrease in inflammatory markers (IL6 and D-dimer) after 12 hours compared to the baseline d. Complications if any during the stay in hospital Timepoint: The Quantitative value of IL6: Before the start of surgery and 12 hours after surgery: The Quantitative value of D-dimer: Before the start of surgery and 12 hours after surgery: | — |
Countries
India
Contacts
Public ContactSubrata Kumar Singha
AIIMS, Raipur
Outcome results
None listed