Health Condition 1: null- arterial and venous thrombosis
Conditions
Interventions
None listed
Sponsors
Department of Clinical Pharmacology
Eligibility
Inclusion criteria
Inclusion criteria: control group: no history of any major illness in the past six months and no personal history of cardiovascular disease or thrombosis, diabetes mellitus, hypertension and hyperlipidemia Patient group: Coronary Artery Disease (CAD) as determined on angiogram, with at least 1 major vessel having more than 75% stenosis or patients with previous history of myocardial infarction or angina pectoris. Patients with evidence of Deep vein thrombosis (DVT) involving lower extremities, abdominal vein as seen on Doppler studies, cortical venous thrombosis (as seen from MR venography) and Pulmonary Embolism (as seen from CT pulmonary angiography). Other eligibility criteria: Patients who are, 1. Attending OPD of Haematology and Cardiology, BYL Nair Hospital 2. Of either sex between the age group from 25-70 years 3. Ready to give written informed consent
Exclusion criteria
Exclusion criteria: age group below 25 years and with any major co-morbid disease condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To determine the prevalence of the MTHFR C677T mutation in healthy Maharashtrian individuals (defined as those speaking Marathi & residing in Maharashtra for the last 3 generations) residing in Mumbai region. 2. To determine the homocysteine concentration and MTHFR C677T mutation in apparently healthy individuals and patients with deep Vein thrombosis and Coronary Artery Disease (CAD).Timepoint: Blood collection once | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate serum homocystine levels in patientsTimepoint: Blood collection once | — |
Countries
India
Contacts
Public ContactDr Renuka Munshi
TN Medical College and BYL Nair Hospital
Outcome results
None listed