Experiment of effectiveness of local administration of an antibiotic named Vancomycin at sternal wound for prevention of wound infection after coronary bypass surgery.

USE OF TOPICAL VANCOMYCIN FOR REDUCTION OF STERNAL WOUND INFECTION IN OFF PUMP CORONARY ARTERY BYPASS SURGERY A PROSPECTIVE RANDOMIZED BLINDED CONTROLLED STUDY.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/08/015382

Enrollment

344

Registered

2018-08-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: null- Sternotomy wound infection

Interventions

Intervention1: topical vancomycin in a form of paste and solution: 500 mg topical vancomycin paste just after sternotomy and 500 mg vancomycin paste just before the closure of sternal wound. Another o

Eligibility

Inclusion criteria

Inclusion criteria: UNDERGOING OFF PUMP CORONARY ARTERY BYPASS SURGERY.

Exclusion criteria

Exclusion criteria: CHRONIC KIDNEY DISEASE(pre-op Serum creatinine more than 2mg/dl or 177microMol/liter. Obesity(BMI more than 30kg/m2). Malnourished(BMI less than 18.5kg/m2). LOCAL SKIN INFECTION. EMERGENCY SURGERY,RE-EXPLORATION OR RE-DO SURGERY. BILATERAL INTERNAL MAMMARY ARTERY GRAFTING. ALLERGIC TO VANCOMYCIN.

Design outcomes

Primary

Measure	Time frame
REDUCTION OF STERNAL WOUND INFECTIONTimepoint: AFTER THREE MONTHS FROM DATE OF SURGERY.	—

Secondary

Measure	Time frame
REDUCTION OF TIME OF MECHANICAL VENTILATION DEPENDENCY AND REDUCED HOSPITAL STAY.Timepoint: TIME OF EXTUBATION AT ITU AND TIME OF DISCHARGE FROM HOSPITAL.	—

Countries

India

Contacts

Public Contactsomnath ghosh

Medical collge and Hospital,Kolkata

drpinakim@rediffmail.com9830384526

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026