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Comparison of two drugs Norepinephrine and Phenylephrine used for the treatment of fall in blood pressure after spinal anaesthesia for Caeserean delivery of uncomplicated pregnancy

Comparison of Norepinephrine vs Phenylephrine boluses for the treatment of hypotension during spinal anaesthesia in patients undergoing Caeserean section. - NEPT

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/08/015364
Enrollment
50
Registered
2018-08-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication Health Condition 2: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Norepinephrine: Norepinephrine is a potent vasopressor with β-adrenergic properties. Recently norepinephrine boluses are being suggested as an alternative to phenylephrine boluses to t

Sponsors

amrita institue of medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Elective CS under spinal anaesthesia, Normal singleton pregnancy beyond 36 weeks gestation, ASA physical status 1 or 2, Weight 50-100 kg, Height 150-180 cm.

Exclusion criteria

Exclusion criteria: Allergy or hypersensitivity to phenylephrine or norepinephrine, Any hypertensive disorders of pregnancy, Cardiovascular or cerebrovascular disease, Fetal abnormalities.

Design outcomes

Primary

MeasureTime frame
To compare number of boluses of norepinephrine vs. phenylephrine required to maintain maternal blood pressure when used to treat post-spinal hypotension in patients undergoing caesarean section.Timepoint: end of surgery

Secondary

MeasureTime frame
To compare the effects of these two drugs on incidence of bradycardia, hypertension, nausea& vomiting in mother and foetal outcomes such as APGAR score & umbilical vein blood gases.Timepoint: end of surgery

Countries

India

Contacts

Public ContactNitu PV

Amrita insititue of medical sciences

nituveesundeep@gmail.com09495962020

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026