Health Condition 1: null- Elderly patients in the age group of 60-80 undergoing any open abdominal surgery irrespective of the type of surgery.
Conditions
Interventions
Intervention1: Dexmedetomidine: AN alpha 2 receptor agonist, administered as a bolus dose of 0.5 micrograms per kg body weight ten minutes prior to induction and maintenance infusion of 0.5 micrograms
Sponsors
Dr Mahendran T Kurup
Dr Puneet Khanna
Eligibility
Inclusion criteria
Inclusion criteria: 1 Age from 60-80 years. 2 Males or Females. 3 ASA grade I and II. 4 Minimum educational level till fifth standard. 5 Undergoing any open abdominal surgery of two hours or more.
Exclusion criteria
Exclusion criteria: 1 Refusal to consent for being a part of the study. 2 Any known allergy to the intervention drugs. 3 Any history of psychiatric or neurologic disorders or previous neurosurgeries 4 Any uncontrolled systemic disease causing an adverse effect on the cognitive function of the patient. 5 Intra-operative profound hypotension or any complication warranting stopping of the intervention agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POCD in both the drug intervention groups. POCD being defined as a fall of more than or equal to 20% in the post-operative neuropsychological test scores as compared to the pre-operative scores. Timepoint: Post-Operative day 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the serum levels of IL-1,IL-6,TNF-alpha & S-100 beta postoperative as compared to preoperative values.Timepoint: post-operative day 3 | — |
Countries
India
Contacts
Public ContactDR PUNEET KHANNA
All India Institute Of Medical Sciences,New Delhi
Outcome results
None listed