To evaluate the effect of low-dose ketamine on inflammation and pain after surgery in patients undergoing laparoscopic hernia repair.

The effect of low-dose ketamine on inflammatory markers and on peri-operative analgesia in patients undergoing laparoscopic hernia surgery- A prospective, randomized, double blind, comparitive study.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/08/015320

Enrollment

Registered

2018-08-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing laparoscopic hernia surgery

Interventions

Intervention1: 1.ketamine: WE will be evaluating the effect of use of low dose ketamine by using it in intra-operatively on inflammatory markers and peri-operative pain Control Intervention1: Normal

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 and elective laparoscopic hernia surgery

Exclusion criteria

Exclusion criteria: consent refusal, recurrent hernia surgeries, unable to understand pain score, laparoscopic surgery converted to open surgery, complicated hernia operation.

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of low dose of ketamine on inflammatory response in patients undergoing laparoscopic hernia surgery.Timepoint: Patients neutrophil lymphocyte ratio and platelet lymphocyte ratio are measured after 2hours of surgery and next day of surgery by keeping the previous day counts as baseline	—

Secondary

Measure	Time frame
â?¢To evaluate the effect of low dose of Ketamine on peri-operative operative pain â?¢ To evaluate the effect of ketamine on pupillary reflex dilatation intraoperatively â?¢ To compare the incidence of emergence delirium, awakening, PONV, shivering, nystagmus. â?¢ To compare the incidence of chronic pain at 3 months Timepoint: pain score and RASS score, PONV score in PACU from end of surgery till 2 hours after the surgery and intra-operative pupillary diameter measurement every 10 minutes.	—

Measure

Time frame

â?¢To evaluate the effect of low dose of Ketamine on peri-operative operative pain â?¢ To evaluate the effect of ketamine on pupillary reflex dilatation intraoperatively â?¢ To compare the incidence of emergence delirium, awakening, PONV, shivering, nystagmus. â?¢ To compare the incidence of chronic pain at 3 months Timepoint: pain score and RASS score, PONV score in PACU from end of surgery till 2 hours after the surgery and intra-operative pupillary diameter measurement every 10 minutes.

—

Countries

India

Contacts

Public ContactShivani Vijaykumar Hallikeri

All India Institute of Medical Science New Delhi

renusinhaagarwal@gmail.com9810305156

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026