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Influence of neutrophil function in stroke

Investigating Metabolic Reprogramming in Stroke as a Consequence of Homocysteine Induced Bidirectional Activation of Neutrophils and Platelets

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/08/015314
Enrollment
200
Registered
2018-08-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I639- Cerebral infarction, unspecified

Interventions

None listed

Sponsors

Science and Engineering Research Board
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: presenting within 7 days of a new onset acute ischemic stroke

Exclusion criteria

Exclusion criteria: subjects with infections, autoimmune diseases and immuno compromised state

Design outcomes

Primary

MeasureTime frame
Present study will lead to identification of novel and distinct mechanisms involved in homocysteine induced NETosis compared to other activators of NETs. This will help in differentiating mechanisms between infection associated NETosis to that of sterile inflammation. Our project also aims to understand metabolic changes in the milieu of neutrophil activation in stroke subjects.Timepoint: 3 years—

Secondary

MeasureTime frame
Findings would facilitate to design new therapeutic targets for clinical management of stroke.Timepoint: 3 years—

Countries

India

Contacts

Public ContactDr Manjunath B Joshi

MAHE Manipal

Manjunath.Joshi@manipal.edu9742561236

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026