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To study the effect of pain killer drug called Clonidine with bupivacaine in anaesthesia given to back(spinal anaesthesia) in caesarean sections surgeries for pain relief.

efficacy of intrathecal clonidine as an adjuvant to hyperbaric bupivacaine in caesarean section : an open labelled randomized control trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/08/015250
Enrollment
98
Registered
2018-08-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication Health Condition 2: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: plain hyperbaric bupivacaine: 12 mg of hyperbaric bupivacaine will be administered intrathecally, once before caesarean section. Control Intervention1: clonidine with bupivacaine hyperb

Sponsors

bangalore baptist hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Previous LSCS. 2. Cephalo-pelvic disproportion 3. Failure of progression of labour. 4. Abnormal foetal presentation

Exclusion criteria

Exclusion criteria: 1. Patients refusal to participate 2. Pregnancy induced hypertension 3. Placenta previa. 4. Antenatal patients with acute fetal distress. 5. Abnormal coagulation profile

Design outcomes

Primary

MeasureTime frame
Primary objective: To compare the duration of sensory block, motor block and analgesia in hyperbaric bupivacaine versus hyperbaric bupivacaine with clonidine as additive in lower segment caesarean sections. Timepoint: to compare onset and duration of sensory block,motor block and analgesia every 5 mins till end of surgery, then every 15 mins till first dose of rescue analgesia

Secondary

MeasureTime frame
1. Comparison of regression of motor block to modified Bromage scale 0 2. Comparison of duration of pain relief (first request for supplemental analgesia), hemodynamic variables and sedation. 3. Comparison of Apgar score of the babies at 1, 5 and 10 minutes (neonatal outcome). Timepoint: every 15 mins pain score assessed using visual analogue score till dose of first rescue analgesia.

Countries

India

Contacts

Public ContactSwati Sujeer

bangalore baptist hospital

docreena1@gmail.com9900610221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 10, 2026