Comparision of two drugs viz; clonidine and dexmeditomidine for lowering blood pressure in surgical correction of facial bones.

Comparison of efficacy of dexmedetomidine and clonidine infusions to produce hypotensive anaesthesia in patients undergoing orthognathic surgery: a randomized controlled trial-Pilot study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/08/015217

Enrollment

Registered

2018-08-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Facial deformity

Interventions

Intervention1: Intravenous Clonidine: loading dose of 2-5 µg/kg clonidine over 20 min, followed by 0.3-2 µg/kg/h Control Intervention1: Intravenouus dexmeditomidine: loading dose of 1µg/kg dexmedetom

Eligibility

Inclusion criteria

Inclusion criteria: American society of anesthesiologists physical status 1 Elective orthognatic surgery

Exclusion criteria

Exclusion criteria: Associated comorbidities Known allergy or contraindication to the use of any of the drugs Patients requiring awake intubation

Design outcomes

Primary

Measure	Time frame
Intraoperative vital parameters ( Heart rate, systolic blood pressure, diastolic blood pessure, mean arterial pressure) Timepoint: every 15 minutes till end of surgery	—

Secondary

Measure	Time frame
Total amount of study drug required Total amount of rescue analgesia Total Blood loss Need for blood transfusion Duration of surgery Quality of surgical field Adverse effects Timepoint: End of surgery to 6 hours post operatively	—

Countries

India

Contacts

Public ContactDevalina Goswami

Centre for Dental Education and Research Centre, All India Institute of Medical Sciences, New Delhi

drdevalina@gmail.com9971196699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026