Role of Vitamin C hydrocortisone and thiamine in critically sick patients (sepsis and septic shock)

Combination of Vitamin C, Hydrocortisone And Thiamine For The Treatment Of sepsis And Septic Shock

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/08/015193

Enrollment

100

Registered

2018-08-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients with a diagnosis of sepsis and septic shock and lactate level more than 2 mmol/l

Interventions

Intervention1: Combination of Vitamin C hydrocortisone and thiamine: Inj vitamin c 1.5 gm iv 6 hourly for 4 days or upto discharge from hospital Inj hydrocortisone 50 mg iv 6 hourly for 1 week followe

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a primary diagnosis of sepsis or septic shock. Patients with a Lactate level of > 2 mmol/L

Exclusion criteria

Exclusion criteria: Patients less than Pregnant patients.

Design outcomes

Primary

Measure	Time frame
2. The primary aim is to study the hospital survival between the treatment and control groups.Timepoint: Outcome will be assesed at two time points 1. In hospital mortality 2. 30 day mortality	—

Secondary

Measure	Time frame
3. Secondary outcomes are duration of vasopressor therapy, requirement for renal replacement therapy in patients with Acute Kidney Injury and the change in serum lactate and the SOFA score over the first 72 hours.Timepoint: at day 1 day 2 day 3 day 4 of hospital stay	—

Countries

India

Contacts

Public ContactDr Saleem Javaid Wani

Sher i kashmir institute of medical sciences

parvaizk@gmail.com9419004822

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026