Health Condition 1: null- post LASIK surgery tear film and ocular surface stability
Conditions
Interventions
Intervention1: E/D chloroquine phosphate 0.03% along with standard treatment: E/D chloroquine phosphate 0.03% BD for 3months along with
standard treatment (E/D Moxifloxacin 0.5% Tds,
E/D Predacetate Q
Sponsors
Dr Jeewan S Titiyal
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients must be 18 years of age or older 2.Stable refractive error for at least 1 year 3.Myopia >=1D and & 4.Astigmatism 5.Minimum calculated residual corneal stromal bed thickness of at least 300µm 6.Patients giving informed consent for trial 7.Patients willing for follow up
Exclusion criteria
Exclusion criteria: 1.Hyperopic patients 2.Patients with pre-operative severe dry eye 3.Patients diagnosed with external ocular disease or history of previous ocular surgery 4.Subjects with permanent or temporary lacrimal punctual occlusion 5.Taking systemic medications likely to affect wound healing, such as corticosteroids and antimetabolites 6.Patients suffering from systemic diseases likely to affect wound healing, such as diabetes,connective tissue disease, and severe atopy; pregnancy or nursing 7.Keratoconus/forme-fruste keratoconus/ Pellucid Marginal Degeneration patients 8.Progressive or unstable myopia and/or astigmatism 9.Previous corneal surgery/Re-surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OSDI score Tear Osmolarity level Tear MMP-9 levelTimepoint: preop, day1, 1week, 1month, 3month, 6month | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear Break Up Time (TBUT) Schirmer Test NEI Score Fluoroscein stain scoreTimepoint: preop, day1, 1week, 1month, 3month, 6month | — |
Countries
India
Contacts
Public ContactDR ANANYA GOSWAMI
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed