Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
Conditions
Interventions
Intervention1: Levamisole: 2.5 mg/kg/day for 1 year
Control Intervention1: Mycophenolate mofetil: 1000 mg/sq.m for 1 year
Sponsors
Jawaharlal Nehru Medical College
Eligibility
Inclusion criteria
Inclusion criteria: 1. Two or more relapses in 6 months while on alternate day levamisole with tapering alternate day prednisolone therapy, or 2. If the prednisolone threshold to maintain remission exceeds 0.7 mg/kg on alternate days or, 3. Patients have significant steroid toxicity (cushingoid with hypertension, ocular toxicity such as cataract, glaucoma or an episode of serious life threatening infection).
Exclusion criteria
Exclusion criteria: 1.Age at onset of nephrotic syndrome less than 1 year or more than 10 year. 2. History of use of alternative treatment other than alternate day levamisole. 3. Biopsy showing pathology other than MCNS. 4. Secondary nephrotic syndrome. 5. Late steroid resistance. 6. Residing >100 km from centre or unwilling to follow up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse frequencyTimepoint: At enrolment, 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects Time to first relapse Proportion of patients relapse-free Cumulative steroid dose used Failure of the trial medication in either groupTimepoint: During 1 year follow up period | — |
Countries
India
Contacts
Public ContactJyotsana Singh
Jawaharlal Nehru Medical College
Outcome results
None listed