Comparison of dexmedetomidine and clonidine for blood pressure, heart rate and anesthetic agents requirement in laparoscopic surgeries

Comparative evaluation of dexmedetomidine and clonidine on propofol consumption, haemodynamics and postoperative recovery in laproscopic surgeries: A prospective,double blind, placebo controlled, randomized study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/07/015137

Enrollment

Registered

2018-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I and II, Non hypertensive and non diabetic

Interventions

Intervention1: Dexmedetomidine: Dexmedetomidine loading dose 1mcg/kg before induction over a period of 15 min and maintenance 0.5 mcg/kg/h throughout the surgery via intravenous (IV) route Intervent

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Non hypertensive and non diabetic

Exclusion criteria

Exclusion criteria: 1. Known allergy to study drug, 2. Morbid obesity (body mass index >40), 3. Chronic use of opioids , 4. Current treatment with a ß-blocker or calcium channel blocker 5. Diabetes and hypertension 6. Known asthma or reactive airway disease, 7. Hepatic, renal or cardiovascular dysfunction 8. Any degree of heart block 9. Psychiatric patients 10. Pregnant and lactating women

Design outcomes

Primary

Measure	Time frame
To study the effect of dexmedetomidine and clonidine on propofol consumption and haemodynamics in laproscopic surgeryTimepoint: Preoperative, After study drug, After induction, After intubation, during pneumoperitoneum 15 min intervals, Post pneumoperitoneum, After Surgery, After extubation	—

Secondary

Measure	Time frame
(1)Postoperative recovery parameters - Extubation time - Response to verbal commands -Time for orientation (2)To study the adverse effects of dexmedetomidine and clonidineTimepoint: Postoperatve period up to 6 hrs	—

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur (C.G.)

smileshweta12@gmail.com7748000222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026