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Compare the effects of anaesthetic drugs on pressure around brain in head down position during surgeries in which gas insuffilated in abdomen

Comparison of sevoflurane, propofol and propofol with dexmedetomidine on intracranial pressure during laparoscopic surgeries in trendelenburg position

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/07/015078
Enrollment
120
Registered
2018-07-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1 & 2 Health Condition 2: I10- Essential (primary) hypertension

Interventions

Control Intervention1: Comparison of Sevoflurane, Propofol and Propofol with Dexmedetomidine on intracranial pressure during laparoscopic surgeries in Trendelenburg position : Comparison of Sevoflura

Sponsors

ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: physical status class 1 or 2 of the age group 18 to 65 years undergoing laparoscopic surgeries with IAP of 12-14 mmHg in trendelenburg position 15°-45°.

Exclusion criteria

Exclusion criteria: 1. Patient refusal to participate in the study 2. Patients younger than 18 years 3. Patient with glaucoma or pre-existing ophthalmic diseases other than myopia or hypermetropia 4. Patient with history of ophthalmic surgery 5. Any acute or chronic ocular infections 6. Patient with neurological illness or history of neurological surgeries 7. Patient with history of allergy to study drugs 8. Patient with history of bradycardia or cardiac conduction defects 9. Body mass index (BMI) greater that 35 kg/m2 10. Patient requiring trendelenburg position of >45°

Design outcomes

Primary

MeasureTime frame
To compare the effect of Sevoflurane, Propofol and Propofol with Dexmedetomidine on Optic nerve sheath nerve diameter (ONSD) as surrogate of ICP in patients undergoing laparoscopic surgeries in Trendelenburg position.Timepoint: one year and six months—

Secondary

MeasureTime frame
1. To evaluate the effect of these anaesthetic techniques on intra-ocular pressure in patients undergoing laparoscopic surgeries in Trendelenburg position. 2. Effect of different anaesthetic techniques on patientâ??s intraoperative haemodynamics and perioperative complications in patients undergoing laparoscopic surgeries in Trendelenburg position.Timepoint: one year and six months—

Countries

India

Contacts

Public ContactDr Sanjeev Kumar Chawriya

All India Institute of Medical Sciences

geetamanoj007@yahoo.co.in9414084584

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026