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Effect of Different Anaesthesia Drugs on Function of Heart

Echocardiographic comparison of left ventricular function using different Anaesthesia Induction techniques

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/07/014997
Enrollment
60
Registered
2018-07-20
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: I350- Nonrheumatic aortic (valve) stenosis Health Condition 3: I060- Rheumatic aortic stenosis Health Condition 4: I712- Thoracic aortic aneurysm, withoutrupture

Interventions

Intervention1: Induction of General Anaesthesia by different anaesthetic agents: Evaluate and compare the changes in echocardiographic parameters of Left Ventricular function upon induction of General

Sponsors

Post Graduate Institute of Medical Education and Research Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex of the age group 18-65 years, undergoing Coronary Artery Bypass Grafting/ Valve replacement or repair surgery/ Combined Coronary Artery Bypass Grafting and Valve surgery/ Combined Valve and ascending aortic procedure/ surgery for correction or palliation of congenital heart diseases

Exclusion criteria

Exclusion criteria: 1.Allergy to any of the drugs to be administered 2. Significant Mitral Annular Calcification 3. Regional dysfunction in the basal myocardial segments 4. Surgical rings or prosthetic mitral valves 5. Severe LV dysfunction (LVEF 6. Pericardial disease 7. Poor echo window 8. Atrial fibrillation/Significant rhythm disturbance 9. H/o steroid use within last 6 months 10. H/o adrenal insufficiency 11. Significant Renal/Hepatic/CNS dysfunction 12. BMI > 35 kg/m2

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the effects of anaesthetic induction by Propofol, Etomidate and Sevoflurane on the echocardiographic parameters of Left Ventricular Function (Peak Global Longitudinal Strain, Septal and Lateral Mitral Annular Sââ?¬â?¢) in adult patients undergoing cardiac surgeries.Timepoint: 1. Baseline 2. Post Induction (Upon reaching target BIS of 50) 3. Post Intubation (Within 1 minute after endotracheal intubation)—

Secondary

MeasureTime frame
To evaluate and compare the effects of anaesthetic induction by Propofol, Etomidate and Sevoflurane on the echocardiographic parameters of cardiac preload (LVEDVI), cardiac afterload (Ea), Left ventricular function (LV ejection fraction, Septal and Lateral Mitral Annular ââ?¬â?¢, Eââ?¬â?¢, Aââ?¬â?¢ velocities, Tei Index, P/V Ratio), Mitral inflow velocities (E velocity, A velocity, E wave deceleration time).Timepoint: 1. Baseline 2. Post Induction (Upon reaching target BIS of 50) 3. Post Intubation (Within 1 minute after endotracheal intubation);To find out correlation between the change in preload and afterload parameters (EDVI, Ea, SVRI) respectively and the change in the systolic function parameters (Peak Global Longitudinal Strain, EF, Tei Index, Septal and Lateral Mitral Annular Sââ?¬â?¢ velocities, P/V ratio) from baseline to that after inductionTimepoint: From baseline to after induction;To observe any side effects of the anaesthetic agents usedTimepoint: Throughout during the Induction and Intubation period—

Countries

India

Contacts

Public ContactProf Goverdhan Dutt Puri

Post Graduate Institute of Medical Education and Research, Chandigarh

gdpuri007@hotmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026