Health Condition 1: null- Melasma
Conditions
Interventions
Intervention1: Tranexamic acid: 500mg Per ora once daily for three months.
Control Intervention1: Hhlite: Mometasone Furoate I.P 0.1% + tretinoin 0.025%+hydroquinone 2.0%, topically used once daily fo
Sponsors
Hindu Mission Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with diagnosis of melasma . 2.Age 18 - 55 years, of either gender. 3.Absence of other confounding inflammatory dermatoses (eg. Exogenous ochronosis, Acanthosis nigricans, post inflammatory hyperpigmentation, Pigmented cosmetic dermatitis, Actinic lichen planus, malar rash, etc.) 4.Willing to follow the study procedures and give written informed consent.
Exclusion criteria
Exclusion criteria: 1.Pregnancy and lactation. 2.Any chronic medical illness, 3.History of thrombosis, abnormal bleeding profile, 4.Any medical treatment for melasma within 1 month of entry, 5.Skin resurfacing by dermabrasion, chemical peels, and facial laser within the preceding 9 months, 6.Hypersensitivity to TXA, 7.Abnormal bleeding time, clotting time or platelet count
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MASI ScoreTimepoint: 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of adverse effects. Patients satisfaction will be evaluated by a Visual Analogic Scale Timepoint: 90 days | — |
Countries
India
Contacts
Public ContactDr Melvin George
Hindu Mission Hospital
Outcome results
None listed