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Role of oral antibiotics in reducing the chance of infection after operations for cancer of the rectum

Role of combined oral antibiotic and mechanical bowel preparation in reducing incidence of surgical site infections in comparison to only mechanical bowel preparation in patients undergoing elective resection for rectal cancer at a tertiary care centre in India : A Randomized Control Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/07/014938
Enrollment
118
Registered
2018-07-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with rectal cancer

Interventions

Intervention1: Oral antibiotic bowel preparation: All the patients in this arm in addition to the bowel preparation solution ( 45 ml of Exelyte bowel preparation solution ( monobasic sodium phosphate

Sponsors

Shriyans Jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients with rectal/ rectosigmoid cancer ( based on MRI imaging ), planned for surgical resection

Exclusion criteria

Exclusion criteria: Patients with rectal cancer who are not eligible for mechanical bowel preparation/ where bowel preparation is contraindicated such as Crohnâ??s disease, obstructed bowel and renal or cardiac impairment.Also patients with known drug allergy to the medications used in the trial.

Design outcomes

Primary

MeasureTime frame
. To evaluate and assess the superiority of oral antibiotic bowel preparation in reducing incidence of surgical site infections in patients undergoing elective resection for rectal cancer in comparison to only mechanical bowel preparation at a tertiary care center in India.Timepoint: 30 days from the day of surgery—

Secondary

MeasureTime frame
To assess the impact of antibiotic bowel preparation on post-operative length of hospital stayTimepoint: 30 days from the day of surgery;To assess the impact of antibiotic bowel preparation on post-operative morbidity.Timepoint: 30 days from the day of surgery—

Countries

India

Contacts

Public ContactMark Ranjan Jesudason

Christian Medical College, Vellore

ranjanbernice@cmcvellore.ac.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026