Health Condition 1: null- Histopathologically confirmed newly diagnosed Glioblastoma, WHO grade IV Health Condition 2: C719- Malignant neoplasm of brain, unspecified Health Condition 3: C719- Malignant neoplasm of brain, unspecified Health Condition 4: G89-G99- Other disorders of the nervous system
Conditions
Interventions
Intervention1: Hypofractionated radiotherapy with concurrent temozolomide followed by adjuvant radiotherapy: second arm will receive hypofractionated radiotherapy with 25 Gray in 5 fractions with conc
Sponsors
Post Graduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histopathologically confirmed newly diagnosed Glioblastoma(GBM), WHO grade IV. 2. Age and KPS (Appendix I) criteria: i) >=65 years old and KPS score of 50-100. ii) 50 to 65 years old and KPS score of 50-70.
Exclusion criteria
Exclusion criteria: Patients who have received prior chemotherapy or radiotherapy. Patients not willing to complete the quality of life questionnaires. Other co-morbidities like diabetes, hypertension, etc. not controlled with medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Overall Survival 2. Progression free survivalTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life assessmentTimepoint: 1 month post radiotherapy,3 months post radiotherapy and 6 months post radiotherapy | — |
Countries
India
Contacts
Public ContactDr Subhash Thakur
Postgraduate Institute of Medical Education & Research
Outcome results
None listed