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ROLE OF SPLENIC ELASTOGRAPHY FOR DIAGNOSIS OF PORTAL HYPERTENSION IN CHILDREN

SPLENIC STIFFNESS BY SHEAR WAVE ELASTOGRAPHY (SWE) FOR NON INVASIVE DIAGNOSIS OF PORTAL HYPERTENSIONAND VARICES IN CHILDREN

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/07/014929
Enrollment
50
Registered
2018-07-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Children less than 14 years with freshly diagnosed cases of Portal Hypertension confirmed by any of 4 parameters: Clinical/Radiological/Histological or Endoscopically

Interventions

Intervention1: Cases: 1. All consecutive freshly diagnosed cases of Portal Hypertension confirmed by any of 4 parameters: Clinical/Radiological/Histological or Endoscopically 2. Age less than 14 year

Sponsors

PGIMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: For Patients 1. All consecutive freshly diagnosed cases of Portal Hypertension confirmed by any of 4 parameters: Clinical/Radiological/Histological or Endoscopically 2. Age less than 14 years For controls 1. Age and Sex matched controls 2. Healthy siblings of patients attending OPD/ IPD or patients with minor intercurrent illnesses 3. Children with body mass index within normal percentiles for age & sex

Exclusion criteria

Exclusion criteria: For Patients 1. Splenomegaly because of other etiologies- hematological/storage/infectious disorder 2. Patients of PHTN with splenectomy or after shunt surgery. 3. Patients receiving pharmacotherapy as primary or secondary prophylaxis 4. Patients receiving treatment for underlying liver disease viz., antivirals, steroids, d-penicillamine, anticoagulation etc., 5. Patients too sick to be transported to the SWE suite For Controls 1. Children with liver disease 2. Abnormal gray-scale US imaging 3. Presence of splenomegaly because of any cause

Design outcomes

Primary

MeasureTime frame
Ability of Spleen Stiffness Measurement (SSM) using Shear Wave Elastography (SWE) technique to predict the presence of Portal Hypertension and Varices In Children with liver diseases of different etiologiesTimepoint: At time of enrollment—

Secondary

MeasureTime frame
1.To study whether SSM differs according to etiology of Portal Hypertension (Prehepatic, Hepatic And Post Hepatic), in children with liver disease 2.To study whether combining Liver Stiffness with Splenic Stiffness as determined by SWE improves the predictive ability to diagnose Portal Hypertension and Varices, in children with liver diseases 3. To suggest normal values of splenic stiffness determined by SWE in healthy children (controls) Timepoint: At time of enrollment—

Countries

India

Contacts

Public ContactSADHNA B LAL

PGIMER

sadhnalal2014@gmail.com9872155573

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026