TO ASSESS THE LOWER JAW FRACTURE HEALING BY USING CALCITONIN HORMONE SPRAY

EVALUATION OF EFFICACY OF CALCITONIN SPRAY ON BONE HEALING FOLLOWING ORIF(OPEN REDUCTION INTERNAL FIXATION) OF MANDIBULAR FRACTURES

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/07/014749

Enrollment

Registered

2018-07-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S026- Fracture of mandible Health Condition 2: null- Patients with ASA 2 criteria

Interventions

Intervention1: Calcitonin nasal spray: Salmon Calcitonin nasal spray 200mcg(1 puff daily)for 30 days Control Intervention1: Nil: Not applicable

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with age group between 20 years to 40 years. 2. Patients with mandibular fractures. 3. Patients with ASA II criteria

Exclusion criteria

Exclusion criteria: 1.Bone pathologies(tumours,cysts etc) 2.Patients with fracture(s) pertaining to regions other than mandible. 3.Patients with recent extraction of tooth/teeth

Design outcomes

Primary

Measure	Time frame
1.To assess that calcitonin promotes a faster bone healing in systemically compromised patients. 2.To assess a better quality of life in these patients by fore said parameters. Timepoint: 1.To collect pre-op blood sample,extract plasma,and assess osteocalcin level. 2.To assess pain by visual analogue scale from post-op day 1 to day 7 followed by assessment after every 7 days,upto 1 month. 3.To collect post-op blood sample after 30th day,extract plasma,and assess osteocalcin level.	—

Measure

Time frame

1.To assess that calcitonin promotes a faster bone healing in systemically compromised patients. 2.To assess a better quality of life in these patients by fore said parameters. Timepoint: 1.To collect pre-op blood sample,extract plasma,and assess osteocalcin level. 2.To assess pain by visual analogue scale from post-op day 1 to day 7 followed by assessment after every 7 days,upto 1 month. 3.To collect post-op blood sample after 30th day,extract plasma,and assess osteocalcin level.

—

Secondary

Measure	Time frame
1. To assess any side-effects of Calcitonin nasal sprayTimepoint: 1. Review patients weekly for four weeks	—

Countries

India

Contacts

Public ContactARITRA ROY

SRM DENTAL COLLEGE,RAMAPURAM,CHENNAI

elavenilomfs@gmail.com9841254653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026