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To test if a A new investigation called Cardiopulmonary testing can be used as an early indicator of heart disease caused by chemotherapy in breast cancer patients and to compare the results with post operative recovery in patients proceeding for surgery without chemotherapy.

Assessment of Cardiorespiratory Dysfunction in Carcinoma Breast Patients Receiving Neo-Adjuvant Chemotherapy Using Cardiopulmonary Exercise Testing and to Evaluate Their Early Post Operative Trajectory with the Carcinoma Breast Patients Posted for Upfront Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/07/014736
Enrollment
60
Registered
2018-07-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with breast cancer

Interventions

None listed

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Carcinoma breast patients willing to take part in the study

Exclusion criteria

Exclusion criteria: 1. Unstable cardiac status (Acute myocardial infarction 3â??5 days, unstable angina, moderate stenoticvalvular heart disease, uncontrolled arrhythmias, syncope, active endocarditis,acute myocarditis or pericarditis,hypertrophic cardiomyopathy, uncontrolled heart failure) 2. Significant pulmonary hypertension 3. Acute pulmonary embolus or pulmonary infarction 4. Electrolyte abnormalities 5. Thrombosis of lower extremities 6. Orthopedic impairment that compromises exercise performance 7. Uncontrolled asthma 8. Pulmonary oedema 9. Room air desaturation at rest 10. Respiratory failure 11. Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise(i.e. infection, renal failure, thyrotoxicosis) 12. Mental impairment leading to inability to cooperate 13. Patient refusal 14. Age 72 years 15. Pregnant patients 16. Emergency surgery

Design outcomes

Primary

MeasureTime frame
To study the changes with respect to cardiopulmonary dysfunction in Cardiopulmonary exercise testing variables in carcinoma breast patients pre chemotherapy and post neo-adjuvant chemotherapy.Timepoint: To study the changes with respect to cardiopulmonary dysfunction in Cardiopulmonary exercise testing variables in carcinoma breast patients pre chemotherapy and post neo-adjuvant chemotherapy.—

Secondary

MeasureTime frame
To assess the difference in functional recovery after the surgery in breast carcinoma patients undergoing upfront surgery Vs breast cancer patients undergoing surgery following neoadjuvant chemotherapy.Timepoint: 6 weeks after surgery—

Countries

India

Contacts

Public ContactDr Sushma Bhatnagar

All India Institute of Medical Sciences

mahhima@gmail.com01129575209

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026