The effect of melatonin in patients with gum disease

Comparative evaluation of melatonin with PRF and PRF alone in periodontal intrabony defects among patients with chronic periodontitis-A Split Mouth Randomised Controlled Trial - PRF- Platelet Rich Fibrin

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/07/014725

Enrollment

Registered

2018-07-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic Periodontitis

Interventions

Intervention1: Melatonin with PRF: Combination of Melatonin and PRF in intrabony defects Control Intervention1: PRF: PRF alone in intrabony defects

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients with chronic periodontitis

Exclusion criteria

Exclusion criteria: Patients with systemic disease, pregnant women, lactating women, patients who are under systemic antibiotics for the past 6 months, patients who have undergone periodontal surgery in the past 6 months.

Design outcomes

Primary

Measure	Time frame
Bone fillTimepoint: 9 months	—

Secondary

Measure	Time frame
Pocket depth, Clinical Attachment Level, Alkaline Phosphatase levelTimepoint: Baseline and 9 months	—

Countries

India

Contacts

Public ContactDr Sankari Malaiappan

Saveetha Dental College

msankari@gmail.com9840285905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026