A study to find whether irrigation with pineapple stem extract can be effective reducing microorganisms in the treatment of periodontitis

Comparative evaluation of antimicrobial efficacy of intrapocket irrigation with 0.2% Chlorhexidine and 4.8 % Bromelain extract on Porphyromonas gingivalis levels in the periodontal pockets - RCT ---- An exploratory study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/07/014721

Enrollment

Registered

2018-07-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Periodontitis patients having atleast one pocket of 5mm or more depth

Interventions

Intervention1: Intra pocket irrigation with 4.8% Bromelain: Subgingival irrigation will be done using a sterile 3 cc syringe with a blunt 23 gauge needle after isolating the area with cotton rolls. Th

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects in age group of 35 to 44 years 2. Subjects having atleast one periodontal pockets of 5mm or more 3. Subjects who will give consent to participate

Exclusion criteria

Exclusion criteria: 1. Subjects on any antibiotic medications 2. Subjects who have undergone periodontal treatment in the past six months 3. Subjects who will be unable to comply with the study appointment schedules 4. Subjects who are known allergic to pineapple or bromelain or chlorhexidine • Subjects with a history of hypertension, diabetes, immunosuppression, hepatic or renal disease, bleeding disorders • Pregnancy • Lactating mothers • Subjects on anticoagulant drugs

Design outcomes

Primary

Measure	Time frame
Reduction in microbial counts of P gingivalis on 7th day after irrigation with 0.2% Chlorhexidine for group B and 4.8% Bromelain for group ATimepoint: Reduction in microbial counts of P gingivalis on 7th day after intrapocket irrigation with 0.2% Chlorhexidine for group B and 4.8% Bromelain for group A	—

Secondary

Measure	Time frame
NilTimepoint: nil	—

Countries

India

Contacts

Public ContactPuja C Yavagal

Bapuji Dental College and Hospital Davangere Karnataka

pujacyavagal@gmail.com09844035470

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026