Health Condition 1: null- Sub fertile women with Poly cystic Ovarian Syndrome
Conditions
Interventions
Intervention1: Letrozole: Sub fertile women with PCOS for ovulation induction
Control Intervention1: Clomiphene Citrate: Sub fertile women with PCOS for ovulation induction
Sponsors
Batiston Decruse Waanbah
Eligibility
Inclusion criteria
Inclusion criteria: All sub fertile women with PCOS (Diagnosis by Rotterdam criteria).
Exclusion criteria
Exclusion criteria: 1. Previously treated with Clomiphene citrate/Letrozole. 2. Chronic kidney disease/ liver disease or any other chronic illnesses. 3. Patients with severe male factor and bilateral tubal blockage. 4. Patients on insulin sensitizers and any other infertility drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovulation rateTimepoint: Ovulation rate/Follicular response is defined as a follicular size following ovulation induction by letrozole of more than or equal to 17 mm on thirteenth day of menstrual cycle in which letrozole at a dose 2.5mg / 5mg / 7.5mg was given daily from day 2 to day 6 of cycle. If a follicular diameter of 14-15 mm is reached, then a repeat ultrasound is done after 2-3 days and a growing follicle (approximately 17 mm) is taken as response. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate per cycleTimepoint: Clinical pregnancy rate per cycle is defined as the number of clinical pregnancies expressed per cycle of ovulation induction.;Clinical pregnancy rate Timepoint: Clinical pregnancy is defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive Clinical signs of pregnancy. In addition to intra-uterine pregnancy, it includes a clinically documented ectopic pregnancy;Cumulative pregnancy rateTimepoint: Cumulative pregnancy rate is defined as pregnancy rate following three ovulatory cycles;Miscarriage rateTimepoint: Miscarriage is defined as spontaneous loss of a clinical pregnancy before 24 completed weeks of gestational age.;Multiple gestation rateTimepoint: Multiple gestation is defined as a pregnancy with more than one embryo or fetus. | — |
Countries
India
Contacts
Public ContactBATISTON DECRUSE WAANBAH
Christian Medical College and Hospital, Vellore
Outcome results
None listed