Comparing the effect of clonidine and pregabalin in reducing heart rate and blood pressure while placement of tube in windpipe during surgery for gall bladder removal.

A comparative evaluation of oral pregabalin and clonidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation during laparoscopic cholecystectomy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/06/014675

Enrollment

Registered

2018-06-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing elective Laparoscopic Cholecystectomy. ASA I and II. Age between 18 to 65 years. Patients of Either Sex.

Interventions

Intervention1: Tablet Clonidine: oral tablet of 0.2 mg, 90 minutes before surgery with a sip of water Control Intervention1: Tablet Pregabalin: oral tablet of 75 mg, 90 minutes before surgery with a s

Eligibility

Inclusion criteria

Inclusion criteria: Undergoing elective Laparoscopic cholecystectomy. ASA I and II.

Exclusion criteria

Exclusion criteria: Anticipated difficult intubation. BMI more than 30. Patient concomitantly on Clonidine or Pregabalin or on Anti hypertensive drugs, Sedatives or hypnotics. Patients with history of cardiovascular , cerebrovascular, neurological and respiratory disease, renal and hepatic dysfunction. Patients with history of allergic reactions to any of the study drugs.

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of oral pregabalin and Clonidine in attenuating the hemodynamic responses to laryngoscopy and intubation.Timepoint: Before premedication (T0). Preinduction (TPREI). Immediately after induction (TP0I). 3 minute after induction (TP0I3). 1(TT1), 3(TT3), 5(TT5) and 10(TT10) minutes after intubation	—

Secondary

Measure	Time frame
to compare the efficacy of Oral pregabalin and clonidine in attenuating the hemodynamic responses to laryngoscopy and intubationTimepoint: Before premedication. Preinduction. Immediately after induction. 3 minute after induction. 1, 3, 5and 10minutes after intubation	—

Countries

India

Contacts

Public ContactDr H C Sachdeva

V.M.M.C. and Safdarjung Hospital

sachdeva_hc04@yahoo.com9868159563

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026