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A randomised control trial to compare reduced dose of anticonvulsant in hypertension in pregnancy and convulsions in pregnancy

Comparison of modified low dose MgSO4 regime with standard pritchard regime in severe preeclampsia and eclampsia: A randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014649
Enrollment
210
Registered
2018-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- PRE ECLAMPSIA AND ECLAMPSIA

Interventions

Intervention1: LOW DOSE MAGNESIUM SULPHATE REGIME: STUDY GROUP WILL BE GIVEN ONLY 10 GM OF MAGNESIUM SULPHATE AS IM LOADING(5 GM IN EACH BUTTOCK)FOLLOWED BY MAINTENANCE DOSE 5 GRAM IN ALTERNATE BUTTO

Sponsors

None listed

Eligibility

Inclusion criteria

Inclusion criteria: All women admitted in Deptt of Obs/Gynae, KGMU,Lucknow,U.P.with eclampsia/severe pre eclampsia

Exclusion criteria

Exclusion criteria: 1.Other causes of convulsions like epilepsy, cerebrovascular accidents, ruptured aneurysm, meningitis, encephalitis, cerebral tumors, hyperventilation syndrome, and metabolic abnormalities. 2.Thromboytopenia 3.Patients already treated outside with magnesium sulphate. 4.Those who present with documented CVA, renal failure (severe oliguria or anuria), massive pulmonary oedema, associated massive hemorrhage, DIC and shock (including sepsis). 5.Patient who has convulsions in front of us before giving loading dose (as that will be an indication for IV MgSO4.

Design outcomes

Primary

MeasureTime frame
1.OCCURANCE OF CONVULSION IN SEVERE PE 2.RECURRENCE OF CONVULSION IN ECLAMPSIATimepoint: 1 YEAR

Secondary

MeasureTime frame
BLOOD LEVELS OF MAGNESIUM SULPHATE BEFORE ADMINISTERING MgSO4 AND AT 15 MIN AND 1 HOUR AFTER GIVING MgSO4Timepoint: 1 YEAR

Countries

India

Contacts

Public ContactMANISHA SHARMA

KGMU,LUCKNOW

anjooa@gmail.com9450401972

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026