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Exploring the reason for malignant transformation of oral submucous fibrosis

ROLE OF EPITHELIAL MESENCHYMAL TRANSITION IN THE PATHOGENESIS OF ORAL SUBMUCOUS FIBROSIS AND ITS IMPLICATIONS IN MALIGNANCY

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/06/014631
Enrollment
140
Registered
2018-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx Health Condition 2: null- Oral submucous fibrosis and Oral submucous fibrosis with malignant transformation

Interventions

None listed

Sponsors

yet to be applied for funding
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed with Oral submucous fibrosis

Exclusion criteria

Exclusion criteria: fibrosis with habit

Design outcomes

Primary

MeasureTime frame
Immunohistochemical(IHC) and gene expression analysis of EMT markers in oral submucous fibrosis and oral squamous cell carcinoma tissues comparing with in-vitro modelsTimepoint: end of 4yrs—

Secondary

MeasureTime frame
compare the primary outcome with in- vitro modelsTimepoint: 2 year, 3 year—

Countries

India

Contacts

Public ContactDr Smitha Sammith Shetty

Faculty of Dentistry, Melaka Manipal Medical College

drsmithashetty@yahoo.co.in9901725862

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026