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A clincal trial to compare the effect of two drugs, ondansetron and granisetron on propofol injection pain

Effectiveness of pretreatment of ondansetron versus granisetron on propofol injection pain.

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014561
Enrollment
120
Registered
2018-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I & II patients undergoing elective surgery under general anesthesia.

Interventions

Intervention1: Pretreatment of patients with ondansetron or granisetron or placebo agent ( normal saline ) prior to induction of anesthesia with propofol to see their effect on reduction in propofol i

Sponsors

B P Koirala Institute Of Health Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I & II Patients undergoing elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Patients allergic to the study drug. 2.History of chronic pain conditions and patients on analgesics or opioids on regular basis. 3.Emergency procedures. 4.Patients of ASA physical status III or more. 5.Known or suspected pregnancy. 6.Patients with peripheral vascular disease. 7.Expected difficult intubation.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of pre-treatment of intravenous ondansetron or granisetron on: Propofol injection pain during induction of anaesthesia.Timepoint: 20 seconds—

Secondary

MeasureTime frame
To observe the effect on post endotracheal intubation hemodynamic responses.Timepoint: 10 minutes—

Countries

Nepal

Contacts

Public ContactDr satyendra Narayan Singh

B.P. Koirala Institute Of Health Scinces

drsnsingh_gp@yahoo.com009779842052189

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026