Clinical study to evaluate the effect of 2% lignocaine injection with alkalinized 2% lignocaine injection for tooth removal

A prospective double blind randomised control trial on efficacy of buffered 2% lignocaine with 1: 80,000 epinephrine versus non buffered solution

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/06/014559

Enrollment

Registered

2018-06-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Injection pain and anesthetic latency in those requiring dental extractions

Interventions

Intervention1: Buffered LA solution: 2% Lignocaine with 1:80,000 epinephrine with 8.4% sodium bicarbonate at a 9:1 ratio Control Intervention1: Non Buffered Local Anesthesia: 2% Lignocaine with 1:80,

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy participants those requiring bilateral dental extractions 2. Patients in the age group of 18- 50 years

Exclusion criteria

Exclusion criteria: 1. Patients with debilitating systemic diseases 2. Patients with renal and cardiac problems 3. Pregnant women 4. Patients having abscess, cyst, space infections associated with teeth to be extracted. 5. Subjects who had analgesic or anti inflammatory drugs 24 hours before treatment 6. Patients allergic to the drugs under study

Design outcomes

Primary

Measure	Time frame
Pain on injection with 5 point Likert ScaleTimepoint: 3-120 seconds on injection	—

Secondary

Measure	Time frame
Anesthetic latency (time of onset) Timepoint: 5 minutes after the injection	—

Countries

India

Contacts

Public ContactKishore Moturi

Vishnu Dental College

moturik@gmail.com9849094159

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026