Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 2: null- Treatment resistant depression
Conditions
Interventions
Intervention1: Electro Convulsive Therapy: ECT is a procedure done under general anesthesia where small electric currents are passed through the brain, intentionally triggering a brief seizure. Patien
cathode would be placed over the right DLPFC. The stimulation would be done with 2mA 20-minute twice daily sessions separated by atleast 3-hours for 5 days.
Sponsors
Ahana Hospitals LLP
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age range 18-60 years 2.Male and Female 3.Written informed consent. 4.Presence of Major Depressive Disorder as per DSM V guidelines 5.Refractory to at least two anti-depressant medications
Exclusion criteria
Exclusion criteria: 1. Co-morbid psychiatric diagnoses such as psychosis, bipolar disorder, substance dependence (including nicotine dependence) 2. Mental retardation, neurological disorders and severe medical illness 3. pregnancy or breast feeding 4.Diagnosis of major depressive disorder with psychotic features during the current depressive episode
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient reported response to treatment [ Time Frame: Acute Study Phase (Baseline Visit to End of Treatment Visit) - approximately 2 weeks ] Response is defined as at least a 50% improvement in Baseline BDI score at End of Treatment Visit. The End of Treatment Visit will occur 2 weeks after the Baseline Visit Timepoint: Patient reported response to treatment [ Time Frame: Acute Study Phase (Baseline Visit to End of Treatment Visit) - approximately 2 weeks ] Response is defined as at least a 50% improvement in Baseline BDI score at End of Treatment Visit. The End of Treatment Visit will occur 2 weeks after the Baseline Visit | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinician reported response to treatment [ Time Frame: Acute Study Phase (Baseline Visit to End of Treatment Visit) - approximately 2 weeks ] Number of patients with an improvement in their Baseline HAM-D score at the End of Treatment Visit. The End of Treatment Visit will occur 2 weeks after the Baseline Visit. Timepoint: Baseline and 2 weeks after the baseline visit | — |
Countries
India
Contacts
Public ContactDrVikhram Ramasubramanian
Ahana Hospitals
Outcome results
None listed