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What are the Risk Factors which may acutely affect neonatal brain in the presence of severe jaundice?

Risk factors for Acute Bilirubin Encephalopathy Among Newborns With Severe Hyperbilirubinemia â?? A Prospective Observational Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/06/014497
Enrollment
80
Registered
2018-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Neonatal jaundice

Interventions

None listed

Sponsors

Maulana Azad Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All consecutive neonates admitted in the unit fulfilling following criteria will be included in the study: 1)Gestational age >=35 weeks, if not ascertainable, then admission weight >1500 g. 2)Postnatal age 14 days or less 3)Total serum bilirubin in the severe hyperbilirubinemia range requiring intervention as per AAP guidelines

Exclusion criteria

Exclusion criteria: 1)Neonates who have undergone exchange transfusion prior to enrollment 2)Neonates with gross congenital malformation

Design outcomes

Primary

MeasureTime frame
Bilirubin/Albumin molar ratio (BAMR) as risk factor for acute bilirubin encephalopathy as per Modified BIND scoreTimepoint: 28 Days—

Secondary

MeasureTime frame
A)Newborn Illness Severity at admission as determined by (score for neonatal acute physiology) SNAP II, haemolytic disorders, perinatal asphyxia, acidosis, temperature instability, hypoglycaemia, sepsis as risk factors for acute bilirubin encephalopathy. B)BERA abnormalityTimepoint: 28 Days 56 Days—

Countries

India

Contacts

Public ContactDr Karamalla Saddam Hussain

Maulana Azad Medical College

ajayneonatology@gmail.com9968604310

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026