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INCREASING POSITIVE END EXPIRATORY PRESSUSE IN VENTILATORY SETTINGS AND NOTING ITS EFFECT ON INTRACRANIAL PRESSURE USING SONOGRAPHIC MEASUREMENT OF OPTIC NERVE SHEATH DIAMETER IN TRAUMATIC BRAIN INJURY PATIENTSâ??

â??TO STUDY THE CORRELATION OF POSITIVE END EXPIRATORY PRESSUSE WITH INTRACRANIAL PRESSURE USING SONOGRAPHIC MEASUREMENT OF OPTIC NERVE SHEATH DIAMETER IN TRAUMATIC BRAIN INJURY PATIENTSâ??

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014455
Enrollment
80
Registered
2018-06-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- TRAUMATIC BRAIN INJURY PATIENTS

Interventions

Intervention1: TRAUMATIC BRAIN INJURY PATIENTS: INCREASING POSITIVE END EXPIRATORY PRESSUSE WITH INTRACRANIAL PRESSURE IN TRAUMATIC BRAIN INJURY PATIENTS AND STUDY THE CHANGE IN INTRACRANIAL PRESSURE

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with severe brain injury (GCS 8 or less) 2.Receiving mechanical ventilation 3.Initial PEEP 4.No history of severe cardiopulmonary disease

Exclusion criteria

Exclusion criteria: 1.Already receiving PEEP > 15 cmH2O at enrollment 2.Intracranial hypertension (defined as ICP > 20 mmHg)

Design outcomes

Primary

MeasureTime frame
â?¢ Association between PEEP and ICP . Intracranial pressure will be measured using sonographic measurements of optic nerve sheath diameter. The association between positive end expiratory pressure and intracranial pressure will be analyzed as the primary outcome. Timepoint: AT THE END OF TRIAL—

Secondary

MeasureTime frame
â?¢ Association between PEEP and cerebral hemodynamics Cerebral hemodynamic information will be recorded and calculated. The association between positive end expiratory pressure and cerebral hemodynamics will be analyzed as a secondary outcome Timepoint: 30 MINUTES—

Countries

India

Contacts

Public ContactSHOBHANA JAFA

KING GEORGES MEDICAL UNIVERSITY LUCKNOW

ng1092@gmail.com9532189279

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026