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Comparison of two drugs for better blood pressure and heart rate control during surgery

EFFECT OF PERIOPERATIVE INFUSION OF MAGNESIUM SULPHATE VERSUS DEXMEDETOMIDINE ON HAEMODYNAMIC RESPONSES IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014453
Enrollment
48
Registered
2018-06-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- scheduled for laparoscopic cholecystectomy under general anaesthesia.

Interventions

Intervention1: dexmedetomidine: dexmedetomidine(loading dose 1mcg/kg intravenous before induction of anaesthesia followed by 0.4mcg/kg/hr till the removal of trocars),haemodynamics measured from T0 to

Sponsors

maulana azad medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • ASA physical status I and II patients in the age-group 18-50 undergoing laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: • History suggestive of allergy to either study drug. • History suggestive of chronic use of antacids. • Chronic alcoholics • BMI >=30 kg/m2 • Known case of diabetes, chronic hypertension, cardiac disease. • Known renal or hepatic insufficiency. • Known case of neuromuscular disorders. • Anticipated difficult airway • Pregnant patients • Patients at risk of aspiration i.e. full stomach, GERD, hiatus hernia etc.

Design outcomes

Primary

MeasureTime frame
Mean Arterial PressureTimepoint: T0: Baseline (after bolus of study drug & prior to administration of fentanyl) T1: Just before PLMA insertion T2 (i), T2 (ii), T2 (iii): 1, 2, 3 minutes after PLMA insertion T3: At peritoneal insufflation T4: 5 minutes after starting peritoneal insufflation T5: Before making 30â?? RTP T6: 5 minutes after 30â?? RTP T7: 5 minutes after flat position T8: 5 minutes after peritoneal deflation T9: Following removal of PLMA T10: At admission to PACU—

Secondary

MeasureTime frame
ï?? SBP ï?? DBP ï?? HR ï?? Sedation Score Timepoint: T0: Baseline (prior to administration of fentanyl) T1: Before PLMA insertion T2 (1 ),T2(2),T2(3): 1,2,3 minutes after PLMA insertion T3: Before peritoneal insufflation T4: 5 minutes after peritoneal insufflation T5: Before making 30â?? RTP T6: 5 minutes after 30â?? RTP T7: 5 minutes after flat position T8: 5 minutes after peritoneal deflation T9: Following removal of PLMA T10: At admission to PACU—

Countries

India

Contacts

Public ContactShefali singh

Maulana azad medical college new Delhi 110002

drakgk@yahoo.co.in9968604219

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026