Health Condition 1: null- american society of anaesthesiology physical status 1 and 2
Conditions
Interventions
Intervention1: pregabalin: Dose-150 mg
Frequency and duration- only once 1 hour before surgery
Route of administration- Oral
properties-GABA agonist
anxiolytic, analgesic, anticonvulsant
Control Inter
Sponsors
kasturba medical college manipal
Eligibility
Inclusion criteria
Inclusion criteria: .ASA grade 1 & 2 .Aged 18 to 65 years .Undergoing elective laparoscopic cholecystectomy under general anaesthesia. .CO2 pneumoperitoneum of atleast 30 minutes duration
Exclusion criteria
Exclusion criteria: 1)Known or suspected allergy to Pregabalin. 2)History of uncontrolled hypertension 3)ASA PS 3/4 patients 4)Cognitive impairement, h/o dizziness 5)Currently using sedatives or anti convulsants 6)Preoperative anticipated difficult air way 7)Layngoscopy duration of >30 seconds or more than 1 attempt of laryngoscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe the efficacy of preoperative oral pregabalin 150 mg on the haemodynamic response to laryngoscopy, intubation and carboperitoneum during laparoscopic cholecystectomyTimepoint: 1)Before premedication 2)1 hour after premdication 3)Following intubation 4)1st minute 5)2nd minute 6)3rd minute 7)4th minute 8)5th minute 9)Before carboperitoneum 10)Following carboperitoneum, 11)5 minutes 12)10 minutes 13)15 minutes 14)30 minutes 15)15 minutes following extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| SedationTimepoint: 1)Before premedication, 2)1 hour after premedication, 3)15 minutes following extubation | — |
Countries
India
Contacts
Public ContactDr Hari Krishna Allu
Kasturba medical college and hospital
Outcome results
None listed