Measure the levels of inflammatory biomarker(MMP-9)in tooth blood sample for checking the outcome of pulp amputation(pulptomy) procedure in infected tooth.

The levels of matrix metalloproteinase(MMP-9) as a prognostic biomarker for the outcome of pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis- A clinical prospective study.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/06/014416

Enrollment

Registered

2018-06-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Teeth with symptomatic irreversible pulpitis without periapical pathology

Interventions

Intervention1: Pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis: Pulpal blood sample will be taken from the pulp chamber for the estimation of MMP-9 followed by MTA pulpotomy

Eligibility

Inclusion criteria

Inclusion criteria: 1-Healthy patient of either gender belonging to 15-35 years of age group. 2-Mandibular molar teeth with established clinical diagnosis of symptomatic irreversible pulpitis without periapical rarefaction 3-Positive response to cold and electric pulp tests 4-Teeth with restorable carious lesions

Exclusion criteria

Exclusion criteria: 1-Teeth with immature roots. 2-Teeth with cracks, cusp fractures, Subgingival caries. 3-Teeth with poor periodontal health, probing pocket depth >3mm, furcation involvement and radiographic horizontal or vertical interdental bone loss. 4-Presence of sinus tract or swelling or periapical pathology on an IOPA radiograph. 5-Patients with systemic conditions which could compromise the healing. 6-Patients not willing to participate in the study.

Design outcomes

Primary

Measure	Time frame
higher the levels of MMP-9 in pulpal blood poorer will be the prognosis of pulpotomy procedure in mature teeth with symptomatic irreversible pulpitisTimepoint: 6 months,12 months	—

Secondary

Measure	Time frame
Clinical and radiographic outcome of pulpotomy procedure in teeth with symptomatic irreversible pulpitis.Timepoint: 6 months, 12 months;evaluatation of the correlation between level of MMP-9 in pulpal blood and time required to achieve hemostasis after pulpotomy in teeth with symptomatic irreversible pulpitisTimepoint: after measuring the level of MMP-9 by ELISA test.;Time required to achieve hemostasis after pulpotomy in teeth with symptomatic irreversible pulpitis.Timepoint: immediately at the point of procedure	—

Measure

Time frame

Clinical and radiographic outcome of pulpotomy procedure in teeth with symptomatic irreversible pulpitis.Timepoint: 6 months, 12 months;evaluatation of the correlation between level of MMP-9 in pulpal blood and time required to achieve hemostasis after pulpotomy in teeth with symptomatic irreversible pulpitisTimepoint: after measuring the level of MMP-9 by ELISA test.;Time required to achieve hemostasis after pulpotomy in teeth with symptomatic irreversible pulpitis.Timepoint: immediately at the point of procedure

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Countries

India

Contacts

Public ContactVijay kumar

All India Institute of Medical Sciences, New Delhi

kumarvijay29@gmail.com9540055001

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026