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Addition of pregabalin before surgery to intravenous lidocaine during surgery and its effect on postoperative pain and stress response

Effect of addition of preoperative oral pregabalin to perioperative intravenous lidocaine infusion on postoperative pain and perioperative stress response in patients undergoing elective laparotomy: A double blind randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014406
Enrollment
82
Registered
2018-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing elective open abdominal surgeries

Interventions

Intervention1: Pregabalin: Preoperative oral pregabalin (150 mg day before surgery, 150 mg on the morning of surgery) Control Intervention1: Placebo: Capsule

Sponsors

JIPMER Intramural fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Undergoing elective open abdominal surgeries, and belonging to ASA I, II and III

Exclusion criteria

Exclusion criteria: Patients sensitive to lidocaine, those suffering from cardiovascular diseases or who had preoperative changes on ECG or Echo, patients on beta blocker or opioid drugs for other indications, patients receiving perioperative pain relief through an epidural catheter, and patients with functional bowel disorders

Design outcomes

Primary

MeasureTime frame
Pain score (as measured on Visual Analogue Scale) postoperativelyTimepoint: 6 hours—

Secondary

MeasureTime frame
Incidence of postoperative nausea and vomitingTimepoint: Hours;Preoperative inflammatory markers (Total leucocyte count, interleukin 6, C-reactive protein)Timepoint: Preoperative, immediate post-op, 24 hours post-op;Time to first passage of stools and flatusTimepoint: Hours—

Countries

India

Contacts

Public ContactJigish Ruparelia

JIPMER, Pondicherry

sarathsistla@hotmail.com9894013556

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026