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Comparison of total Vitamin D blood levels with its biologically active free form in children with Steroid Sensitive Nephrotic Syndrome.

Is free 25-hydroxycholecalciferol (25(OH)D) a better marker of bone metabolism compared to total 25(OH)D in Steroid Sensitive Nephrotic Syndrome?

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/06/014401
Enrollment
200
Registered
2018-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Children with steroid sensitive nephrotic syndrome.

Interventions

None listed

Sponsors

Institute of Child Health
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cases: Children with Nephrotic Syndrome attending outpatient clinic. Controls: healthy children attending immunisation or well baby clinics.

Exclusion criteria

Exclusion criteria: 1) Patients having steroid resistant nephrotic syndrome 2) Atypical features suggesting secondary NS: haematuria, hypertension, renal failure, rash, arthritis. 3) Patients or controls having any other acute or chronic illness 4) Patients or controls requiring hospitalisation 5) Patients or controls who received vitamin D therapy in the last 6 months

Design outcomes

Primary

MeasureTime frame
1. measured serum levels of VDBP 2. measured serum levels of total 25(OH)D 3. measured serum levels of free (bioavailable) 25(OH)D 4. calculated levels of bioavailable 25(OH)D Timepoint: Cases: During Relapse of Nephrotic Syndrome and when in Remission for 1 month. Controls: single sample taken at recruitment—

Secondary

MeasureTime frame
assess correlations between serum free / total 25(OH)D levels and serum ALP and PTHTimepoint: At study end—

Countries

India

Contacts

Public ContactDr Sushmita Banerjee

Institute of Child Health, Kolkata.

asban@vsnl.com9830023975

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026