Health Condition 1: null- Preterm infants
Conditions
Interventions
Intervention1: Magnesium Sulphate plus standard of care: A bolus of 4 g(8ml) Magnesium Sulphate(50% w/v) in 12ml normal saline intravenously (IV) over 20 minutes followed by infusion of Magnesium Sulp
Sponsors
PGIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1. Gestational age less than or equal to 32 weeks 2. Singleton or multiple pregnancy at risk for preterm delivery within the next 24 hours 3. Active preterm labor with cervix 4â??8 cm dilated or preterm premature rupture of membranes or Indicated preterm birth within the next 24 hours
Exclusion criteria
Exclusion criteria: 1. Maternal contraindications to receiving magnesium sulfate like renal failure, cardiac arrhythmia, myasthenia gravis, hypersensitive to drug, heart block, diabetic coma, electrolyte disorder 2. Preeclampsia, eclampsia 3. Fetal distress, abruptio placenta, severe antepartum hemorrhage where urgent delivery is indicated. 4. Precipitate labor 5. Chorioamnionitis 6. Major fetal abnormalities 7. Intrauterine fetal death
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined outcome of mortality or abnormal neurodevelopmental outcome at 6 months of corrected age as determined by developmental assessment scale for Indian infants (DASII)Timepoint: after birth to 6 months of corrected age | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Neurodevelopmental outcome as determined by developmental assessment scale for Indian infants (DASII)Timepoint: 6 months;Maternal adverse events following magnesium sulphate infusionTimepoint: till maternal discharge;Neonatal mortalityTimepoint: after birth | — |
Countries
India
Contacts
Public ContactGeeta Gathwala
Pt B D Sharma PGIMS Rohtak
Outcome results
None listed