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Examining the efficacy of brain stimulation for a neuropsychiatric disorder called OCD

Neurobiological correlates and translational implications of neuromodulation in OCD: A high definition transcranial direct current stimulation (HD-tdcs) study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/06/014360
Enrollment
140
Registered
2018-06-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with Obsessive Compulsive Disorder

Interventions

Intervention1: Active HD tDCS: HD tDCS - a non-invasive brain stimulation technique will be used as active arm/ intervention arm. Active HD tDCS will be offered to those participants who show less t

Sponsors

National Institute of Mental Health And Neurosciences NIMHANS Bangalore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1. Diagnosis of OCD as per DSM-V criteria (American Psychiatric Association, 2013) 2. Age Range: 18 â?? 50 Years 3. Either Sex 4. Right-handedness 5. Stable psychotropic medications atleast for 12 weeks and not on cognitive behavioral therapy presently 6. Persistent symptoms despite adequate SSRI treatment (OCD symptom severity according to Yale Brown Obsessive Compulsive Scale score of atleast 16) Healthy controls: Right handed;age,sex and education matched

Exclusion criteria

Exclusion criteria: 1. Comorbid psychosis, bipolar disorder, substance dependence (including nicotine dependence) features suggestive of psychiatric emergency (for example: suicidal risk, catatonia, prolonged nutritional deprivation, aggression or excitement) 2. Any contraindication to HD-tDCS procedure-(i) metal in the head,(ii) implanted brain medical devices,(iii)local lesion or injury in the scalp / head 3. Co-morbid neurological/medical disease that can affect the brain structure/function

Design outcomes

Primary

MeasureTime frame
Functional MRI (fMRI)- Resting fMRI and with cognitive activation task(Symptom provocation paradigm followed by Stop-signal task)Timepoint: Baseline and after 10 days of HD tDCS sessions—

Secondary

MeasureTime frame
Magnetic resonance Spectroscopy â?? MRS for NAA and glutamate in-vivo signals at pre-SMA Error Related Negativity (ERN) Clinical assessments - illness severity ratingsTimepoint: Baseline and after 10 days of HD tDCS sessions—

Countries

India

Contacts

Public ContactJanardhanan C Narayanaswamy

National Institute of Mental Health And Neurosciences

jairamnimhans@gmail.com08026995837

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026