A study to compare the effects of a drug (dexmedetomidine) in chest wall nerve blocks (Pec 1 and Pec 2 blocks) for pain relief during and after surgery in breast cancer patients.

Dexmedetomidine as an adjuvant to bupivacaine in ultrasound guided Pec 1 and Pec 2 blocks for perioperative analgesia in mastectomy patients.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014334

Enrollment

Registered

2018-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- 1.Female patients in the age group of 18 to 65 years. 2.ASA Grade I or II 3.Patients posted for elective modified radical mastectomy.

Interventions

Intervention1: Dexmedetomidine 0.5 microgram per kilogram body weight.: Patients in Group Bd would receive Pec 1 and Pec 2 block with 30 ml 0.25% bupivacaine with dexmedetomidine 0.5 microgram per kil

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients of ASA Grade I or II. 2.Patients posted for elective modified radical mastectomy.

Exclusion criteria

Exclusion criteria: 1.Patient is not giving informed consent. 2.Patients with BMI >35 kg/square metres. 3.Patients with sensitivity to local anaesthetics. 4.Patients with bleeding disorders or on anticoagulants. 5.Patients with spine or chest wall deformityor pregnancy. 6.Patients with local infection at the site of block. 7.Patients with significant neurological,cardiac,renal,hepatic or pulmonary disease. 8.Patients planned for breast conservative surgery or simple mastectomy with axillary clearance.

Design outcomes

Primary

Measure	Time frame
1.Quality of postoperative analgesia which would be assessed using VAS score. 2.Duration of analgesia (time to first rescue analgesia after administration of block). 3.Intraoperative hemodynamic parameters (mean blood pressure and heart rate). 4.Total analgesic consumption intraoperatively and in first 24 hours after surgery.Timepoint: 1.The VAS score would be assessed at 0,15,30,60 minutes over first 4 hours postoperatively and then at every 2 hours for first 12 hours and at every 4 hours for next 12 hours. 2.Total analgesic consumption intraoperatively and in first 24 hours after surgery.	—

Measure

Time frame

1.Quality of postoperative analgesia which would be assessed using VAS score. 2.Duration of analgesia (time to first rescue analgesia after administration of block). 3.Intraoperative hemodynamic parameters (mean blood pressure and heart rate). 4.Total analgesic consumption intraoperatively and in first 24 hours after surgery.Timepoint: 1.The VAS score would be assessed at 0,15,30,60 minutes over first 4 hours postoperatively and then at every 2 hours for first 12 hours and at every 4 hours for next 12 hours. 2.Total analgesic consumption intraoperatively and in first 24 hours after surgery.

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Secondary

Measure	Time frame
1.Presence of any adverse effects like hypotension,nausea,vomiting,respiratory depression and sedation score.Timepoint: The secondary outcomes are assessed immediately after surgery and for first 24 hours in postoperative period.	—

Countries

India

Contacts

Public ContactDr Vijit Kumar

King George Medical University Lucknow,UP-226003

dr.p.rajsingh@gmail.com9918478136

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026