Health Condition 1: null- Pain in Acute pancreatitis
Conditions
Interventions
Intervention1: Intravenous diclofenac: Intravenous diclofenac 1 mg/kg was administered in adult patients with acute pancreatitis presenting within 3 days of onset of pain as a 2nd comparator arm of t
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Informed consent. 2. Patients more than 18 years of age. 3.Acute pancreatitis as defined by clinical symptoms, elevated serum amylase (more than thrice the upper limit of normal range) or imaging findings. 4. Patients who have presented to the hospital within the first 3 days after onset of pain. 5. Alert and oriented at admission.
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Patients with significant chronic hepatitis, anaemia and agranulocytosis. 3.Patients of acute pancreatitis who have renal failure (Serum Creatinine >= 1.4 mg/dl) at presentation 4.Patients who were contraindicated to Opioids and NSAIDS 5. Patients Who already are taking or have taken opioids and NSAIDS for other reasons ï??No written informed consent ï??Deaths during study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Number of participants showing improvement in pain intensity. 2.Number of participants requiring supplementary analgesia (offered when trial drug intervention fails to relieve pain). Timepoint: Pain scores were recorded after first hour (VAS1) of administration of the drug and subsequently every 3 hours by a blinded researcher using the VAS for assessing pain intensity. The study medication was limited to maximum period of seven days and stopped earlier if there was no further need for analgesia. A painless day was defined as being a day when a patient mark zero on VAS. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Number of participants with pancreatitis complications. 2.Number of participants with drug related adverse events. 3.To determine correlation between lipase concentration on admission and dose of analgesia requirement. 4.Number of deaths from any cause. Timepoint: No time point | — |
Countries
India
Contacts
Public ContactDr Santosh Kumar Nadipalli
PGIMER chandigarh
Outcome results
None listed