Comparison of different drug combinations with respect to changes in pulse rate and blood pressure during induction of anaesthesia.

Comparison of the haemodynamic responses to laryngoscopy and intubation on induction with Etomidate, Propofol-Ketamine or Propofol-Etomidate

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014307

Enrollment

Registered

2018-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing elective procedures under general anaesthesia requiring endotracheal intubation.

Interventions

Intervention1: Propofol and Ketamine: Ketamine 1 mg/kg followed by Propofol 1 mg/kg for induction of anaesthesia Intervention2: Propofol and Etomidate: Etomidate 0.15 mg/kg followed by Propofol 1 mg/k

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status 1 and 2 patients

Exclusion criteria

Exclusion criteria: Known history of hypersensitivity to etomidate, propofol or ketamine, egg or soya; BMI >30 kg/sq.m; History of postural hypotension, diabetes mellitus, cardiovascular diseases; GERD; Pregnancy; Anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
Mean Arterial PressureTimepoint: Baseline; After midazolam and Fenatnyl; after induction agent; just prior to laryngoscopy; 1,2,3,4,5,7 and 10 minutes after intubation.	—

Secondary

Measure	Time frame
1. Systolic and diastolic blood pressure 2. Changes in heart rate 3. BIS values 4. Requirement for rescue intervention.Timepoint: Baseline; After midazolam and Fenatnyl; after induction agent; just prior to laryngoscopy; 1,2,3,4,5,	—

Countries

India

Contacts

Public ContactMalvika Gupta

Maulana Azad Medical College

ucverma2k@gmail.com9968604211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 20, 2026