To compare two different doses of a drug (Dexmedetomidine which is used as an additive in spinal anaesthesia) by using it together with another drug( levobupivacaine which is a local anaesthetic drug used in spinal anaesthesia) for spinal anaesthesia in lower abdominal surgeries

Comparative evaluation of two different doses of dexmedetomidine as an adjunct to levobupivacaine for subarachnoid block for lower abdominal surgeries

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/05/014273

Enrollment

100

Registered

2018-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing lower abdominal surgeries planned for spinal anaesthesia

Interventions

Intervention1: Levobupivacaine with dexmedetomidine: Two different doses of dexmedetomidine 2.5 micrograms and 5 micrograms with levobupivacaine(15mg) Control Intervention1: Not applicable: Not applic

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and gradeII patients patients with weight from 45kgs to 85kgs patients with height not less than 150 cms Patients undergoing lower abdominal surgeries

Exclusion criteria

Exclusion criteria: Patients refusal to be a part of the study Previous spinal surgeries( technically difficult subarachnoid block) Spine deformities Local site infection and coagulation abnormalities, allergy to local anaesthetics or study medications neuromuscular diseases patients with hematological , neurological and psychiatric diseases patients with heart block ,dysrrthymias and labile hypertension

Design outcomes

Primary

Measure	Time frame
To study block characteristics in terms of onset, duration of sensory and motor block in patients posted for lower abdominal surgeries. Timepoint: Intraoperatively every 2 minutes for a period of 20 minutes then every 30 minutes till end of surgery then every 15 minutes in post anesthesia care unit till patient is discharged from there	—

Secondary

Measure	Time frame
To compare hemodynamic parameters - heart rate, systolic diastolic and mean arterial pressure and SPO2 when two different doses of dexmedetomidine are used as an adjunct to levobupivaicaine for spinal anaesthesia in lower abdominal surgeries.Timepoint: every 1 minute till 10 minutes , every 5 minutes till completion of surgery , every 15 minutes in post anaesthesia care unit	—

Countries

India

Contacts

Public ContactDr Srishti Verma

King Georgeâ??s Medical University

dr.jyotsna@yahoo.co.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026