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Comparison of the performance of two pain monitoring devices Analgesia Nociceptive Index ( derived from ECG) and Surgical Pleth Index ( derived from pluse oximetry) in the setting of sudden blood loss during surgery.

Performance of Analgesia Nociceptive Index and Surgical Pleth Index during acute blood loss during surgery.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/05/014265
Enrollment
50
Registered
2018-05-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with Traumatic brain injury ( Acute subdural hematoma, Extradural hematoma, contusions), meningioma undergoing surgery

Interventions

Control Intervention1: Analgesia Nociceptive Index, Surgical Pleth Index: Comparison of the performance of two pain monitoring devices Analgesia Nociceptive Index and Surgical Pleth Index during acute

Sponsors

National Institute of Mental Health and Neurosciences NIMHANS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Expected blood loss > 500 ml. 2. Highly vascular meningioma based on CT/ MRI/ DSA.

Exclusion criteria

Exclusion criteria: Patients with bilateral head injury (similar extent of injury on opposite side), Patients with baseline heart rate > 100 bpm after intubation and fluid resuscitation, Patients on treatment with beta blockers, clonidine,neostigmine, atropine, glycopyrrolate, Patients with known drug allergy to local anaesthetics, Pregnancy, Patients with cardiac arrhythmias, Duration of surgery Baseline Haemoglobin (Hb) Patients refusing to give consent

Design outcomes

Primary

MeasureTime frame
Change in the values of ANI and SPI intraoperatively during acute blood loss in patients undergoing surgery for traumatic brain injury (subdural, extradural hematoma and contusions) and supratentorial meningiomasTimepoint: During blood loss every 5 minutes—

Secondary

MeasureTime frame
To study the effect of Noradrenaline on the values of ANI and SPI in the event of hypotension during acute blood loss intraoperativelyTimepoint: Every 5 minutes in an event of hypotension during acute blood loss intraoperatively.—

Countries

India

Contacts

Public ContactSindhu Priya M

National Institute of Mental Health and Neurosciences (NIMHANS)

gsuma123@yahoo.com9738616282

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026