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Comparison of Two Drugs Ephedrine And Mephentermine for the Management of Fall in Blood Pressure Following Spinal Anaesthesia in Caesarean Section

Comparison of Bolus Ephedrine and Mephentermine for Management of Spinal Induced Hypotension in Caesarean Section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/05/014238
Enrollment
60
Registered
2018-05-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Undergoing elective LSCS

Interventions

Intervention1: Ephedrine group: Will receive Ephedrine 6 mg I.V. bolus Control Intervention1: Mephentermine group: Will receive Mephentermine 6mg I.V. bolus

Sponsors

Dr Linette Serah Thomas
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women posted for elective LSCS with singleton pregnancy of 39-41 weeks of gestation. 2. Age between 20-40 years. 3. Weight between 45-70 kg. 4. Height between 145-160 cm 5. Women belonging to ASA I category

Exclusion criteria

Exclusion criteria: 1. Parturients with obstetric complications like pregnancy induced hypertension (PIH), obesity, pre-existing hypertension, cardiovascular diseases, cerebrovascular diseases and gestational diabetes. 2. Evidence of foetal anomalies. 3. Patients who are contraindicated for spinal anaesthesia.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of Ephedrine and Mephentermine in preventing and treating maternal hypotension after spinal anaesthesia in caesarean section.Timepoint: September 2019—

Secondary

MeasureTime frame
1. To evaluate vasopressor therapy-related adverse effects. 2. To compare foetal changes through Apgar scores and umbilical cord arterial and venous blood gases.Timepoint: 2—

Countries

India

Contacts

Public ContactDr Linette Serah Thomas

Father Muller Medical College

drgurumurthy@rediffmail.com9448026663

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026